The Science of Stress and Inflammation—And What to Do About It

Stress isn’t just a mental state—it leaves a biological trail. When stress becomes chronic, your body increases production of cortisol, a hormone that helps you respond to immediate threats. But when cortisol remains elevated, it disrupts the normal balance of the immune system, raising levels of inflammatory cytokines like interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). This state of low-grade, persistent inflammation is a known contributor to a wide range of conditions—from fatigue and brain fog to insulin resistance and cardiovascular issues.

When your stress response is always “on,” your body shifts resources toward short-term survival. Digestion slows. Sleep gets interrupted. Muscle recovery lags. And essential nutrients—especially B vitamins, magnesium, and omega-3s—are depleted more quickly. This combination accelerates the breakdown of your body’s natural repair systems, leaving you physically and mentally exhausted, even when you’re not doing much.

There’s growing evidence that inflammation and mood are biologically intertwined. Elevated inflammatory markers have been observed in people with anxiety and depression. One meta-analysis in JAMA Psychiatry found that patients with major depressive disorder consistently had higher CRP levels. Another study published in Molecular Psychiatry showed that inflammation can disrupt serotonin metabolism, affecting mood regulation. Fortunately, the reverse is also true: reducing inflammation can improve mood, resilience, and cognitive function.

That’s where targeted lifestyle and nutritional strategies come in. Gentle daily movement (like walking or yoga), deep restorative sleep, and an anti-inflammatory diet rich in whole foods are critical. But micronutrient support plays a foundational role too. Nutrients like Omega-3 fatty acids (especially EPA), Vitamin D, Magnesium, and B vitamins have all been shown to lower inflammation and support neurotransmitter function. Taken consistently, they help your nervous system reset, giving your body a chance to recover and rebuild.

Planet 3 Vitamin Packs include these key nutrients—Omega-3s, Vitamin D, Magnesium, and B vitamins—so your stress doesn’t turn into something chronic.